重组人促红细胞生成素(EPO)

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规格: 10μg

英文名字：Erythropoietin(EPO),Human,Recombinant(C-6His)

质量标准：>95%,BR

- 重组人促红细胞生成素(EPO) 数量

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SKU： MA1312-1

分类： 其他细胞因子, 细胞因子及重组蛋白, 细胞生物学

描述

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Source:

Human Cells

Description:

Recombinant Human Erythropoietin is produced by our Mammalian expression system and the target gene encoding Ala28-Arg193 is expressed with a 6His tag at the C-terminus.

Accession:

P01588

Known As:

Erythropoietin; Epoetin; EPO

Predicted Mol Mass:

19.2 Kda

Apparent Mol Mass:

30-40 kDa, reducing conditions

Endotoxin:

< 1 EU/µg as determined by LAL test.

Formulation:

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Reconstitution:

Always centrifuge tubes before opening.Do not mix by vortex or pipetting.

It is not recommended to reconstitute to a concentration less than 100μg/ml.

Dissolve the lyophilized protein in distilled water.

Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Shipping:

The product is shipped at ambient temperature.

Upon receipt, store it immediately at the temperature listed below.

Storage:

Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.

Reconstituted protein solution can be stored at 2-8°C for 2-7 days.

Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

Background:

Erythropoietin (EPO) is a glycoprotein hormone that is principally known for its role in erythropoiesis, where it is responsible for stimulating proliferation and differentiation of erythroid progenitor cells. Erythropoietin is a member of the EPO/TPO family. It is a secreted, glycosylated cytokine composed of four alpha helical bundles. The differentiation of CFU-E (Colony Forming Unit-Erythroid) cells into erythrocytes can only be accomplished in the presence of EPO. Physiological levels of EPO in adult mammals are maintained primarily by the kidneys, whereas levels in fetal or neonatal mammals are maintained by the liver. EPO also can exert various non-hematopoietic activities, including vascularization and proliferation of smooth muscle, neural protection during hypoxia, and stimulation of certain B cells. Genetic variation in erythropoietin is associated with susceptbility to microvascular complications of diabetes type 2. These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy.

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